High Sensitivity and Large Dynamic Range Surface Plasmon Resonance Sensing for DNA Hybridization Using Au-Nanoparticle-Attached Probe DNA

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  • Hayashida Masayuki
    Research Institute for Electronic Science, Hokkaido University CREST-JST, Hokkaido University
  • Yamaguchi Akira
    Department of Chemistry, Graduate School of Science, Tohoku University
  • Misawa Hiroaki
    Research Institute for Electronic Science, Hokkaido University CREST-JST, Hokkaido University

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Abstract

In this study, we demonstrate the use of surface plasmon interaction between Au nanoparticles (GPs) and a Au thin film for enhancement of surface plasmon resonance (SPR) spectroscopy sensing for DNA hybridization. In situ DNA hybridization with a Au-nanoparticle-attached probe DNA (DNA-GP) monolayer is monitored by SPR spectroscopy, and the results reveal that the DNA-GP allows detection of unlabeled target DNA with the large dynamic range of 1 pM to 10 μM.

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