書誌事項
- タイトル別名
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- METABOLIC STUDIES ON TICARCILLIN IN EXPERIMENTAL ANIMALS AND HEALTHY VOLUNTEERS
- ジッケン ドウブツ オヨビ ケンコウ シガンシャ ニ オケル Ticarcil
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Serum levels, urinary and biliary excretions, and tissue distribution of ticarcillin (TIPC) were, determined after a single intramuscular dose of 20 mg/kg in rats, rabbits and dogs. Marked differences in serum levels and half-life of TIPC were found among different species of the animals used. Serum levels of TIPC in dogs were clearly dose-related after single intramuscular doses of 20, 40, and 80 mg/kg. The urinary and biliary recoveries and tissue distribution were similar to those of carbenicillin.<BR>Serum levels and urinary excretion of TIPC after a single intravenous dose of 1 g were determined in 6 healthy volunteers, and the mean serum level peaked at 91. 8 μg/ml 15 minutes after injection. The 8-hour urinary recovery of TIPC and its penicilloate averaged 79. 7 and 14. 8% respectively. The serum levels of TIPC in the 6 volunteers were analyzed using a two compartment open model, and the pharmacokinetic parameters were calculated to simulate serum levels of the antibiotic after drip infusion of different doses or various periods.
収録刊行物
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- CHEMOTHERAPY
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CHEMOTHERAPY 25 (9), 2453-2462, 1977
公益社団法人 日本化学療法学会
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詳細情報 詳細情報について
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- CRID
- 1390001206277758976
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- NII論文ID
- 130004071105
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- NII書誌ID
- AN00186653
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- ISSN
- 18845894
- 00093165
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- NDL書誌ID
- 1914845
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- データソース種別
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- JaLC
- NDL
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可