PHARMACOLOGICAL STUDIES ON CARBENICILLIN

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  • ONISHI REIKO
    Department of Pharmacology, Hiroshima University, School of Medicine
  • ARATANI HARUE
    Department of Pharmacology, Hiroshima University, School of Medicine
  • NAKAGAWA AKIRA
    Department of Pharmacology, Hiroshima University, School of Medicine

Bibliographic Information

Other Title
  • Carbenicillinに関する薬理学的研究
  • Carbenicillin ニ カンスル ヤクリガクテキ ケンキュウ

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Description

Some Pharmacological actions of carbenicillin (disodium α-carboxybenzylpenicillin), a new semisynthetic penicillin, were investigated. No effects were obser ved on the blood pressure and respiration in anesthetized rabbit intravenously given carbenicillin 100 mg/kg; on the excised atrium of guinea-pig and heart of toad in 10-3g/ml carbenicillin concentration; and on the excised intestine of rabbit in 10-3g/ml. The perfused rabbit ear vessels was given no effect by carbenicillin 10-4 g/ml, but was slightly contracted by high concentration as 10-3-10-2 g/ml. Carbenicilli n had also no effects on the actions of adrenaline and acetylcholine in the blood pressure of rabbit, or on the actions of adrenaline, acetylcholine and histamine in the excised rabbit intestine. When carbenicillin was infused into the cisterna magna of rabbit or the cerebrum of m ouse, the convulsions were not typical and not specific. It is indicated that carbenicillin has almost no effects on the functions of autonomic nervous system, cardiovascular system, movement of smooth muscle and central nervous system. Furthermore, it is concluded that carbenicillin has less pharmacological actions than penicillin-G and other semisynthetic penicillins (phenoxypropyl-, phenoxyethyl-, aminobenzyl- and methylchlorophenylisoxazolyl-penicillin) except dimethoxyphenyl-penicillin.

Journal

  • CHEMOTHERAPY

    CHEMOTHERAPY 17 (7), 1111-1116, 1969

    Japanese Society of Chemotherapy

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