ACTIVITY OF CARBENICILLIN ON PSEUDOMONAS AERUGINOSA

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  • HOMMA YUZURU
    Department of Bacteriology, The Institute of Medical Science, The University of Tokyo
  • KUMAZAWA YOKO
    Department of Bacteriology, The Institute of Medical Science, The University of Tokyo
  • YOKOTE NORIKO
    Department of Bacteriology, The Institute of Medical Science, The University of Tokyo

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Other Title
  • Carbenicillinの緑膿菌に対する作用
  • Carbenicillin ノ リョクノウキン ニ タイスル サヨウ

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Description

Activity of carbenicillin on Pseudomonas aeruginosa was investigated with the following results.<BR>1) Two kinds of dissociants “type la” and “type sm” isolated from each of the 15 str ains, were tested and compared with each other. No difference could be found between the two types except in one case.<BR>2) Eighty-eight strains of Ps. aeruginosa were tested on their sensitivity to carbenicillin and found quite different from each other. The minimum inhibitory concentration (M. I. C. ) of each of the strains was found scattered over a wide range, the concentration difference between the extremities bein g 2". About 50 per cent of the 88 strains, however, as found to have M. I. C. of 50 mcg/ml, and about 80 per cent of them within a range from 25 mcg/ml to 100 mcg/ml.<BR>3) No correlation was found between the sensitivity of Ps. aeruginosa against carbenicillin and the one against other antibiotics PC-G, KM, SM, CP, GM, PL-B and CL. Among strains that were found resistant to the latter antibiotics, which were effective to Ps. aeruginosa, there were some that were sensitive to carbenicillin. There were also found some strains that were resistant to CL-M, while at the same time sensitive to both PL-B and GM. Therefore, it will be advisable in clinical application of Ps. aeruginosa to test them on their sensitivity against each of antibiotics which are supposed to be effective to Ps. aeruginosa.<BR>4) Among the 10 kinds of stra ins classified by serological typing (cf. reference 2) could be found no difference in sensitivity to carbenicillin.<BR>5) Protoplast formation could be observed by phase microscopy in either case whether a strain sensitive to carbenicillin (0. 78 mcg/ml) or a strain resistant to it (400 mcg/m1) was used. Further studies are needed to clarify the chemico-physical and biological properties of the protoplast.

Journal

  • CHEMOTHERAPY

    CHEMOTHERAPY 17 (7), 1106-1110, 1969

    Japanese Society of Chemotherapy

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