REPRODUCTION STUDIES OF SODIUM COLISTIN METHANESULFONATE (CLM). I FERTILITY STUDY IN MICE

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  • SAITOH TARO
    Pharmacological Research Center, Kayaku Antibiotic Research Co., Ltd.
  • TSUJITANI MICHIHIKO
    Pharmacological Research Center, Kayaku Antibiotic Research Co., Ltd.
  • OHUCHI MASARU
    Pharmacological Research Center, Kayaku Antibiotic Research Co., Ltd.
  • MATSUMOTO TOMONORI
    Pharmacological Research Center, Kayaku Antibiotic Research Co., Ltd.

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Other Title
  • コリスチニメタンスルホン酸ナトリウム（ＣＬＭ）のマウスにおける生殖試験　Ｉ　　妊娠前および妊娠初期投与試験
  • Sodium colistin methanesulfonate CLM ノ
  • 妊娠前および妊娠初期投与試験

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Abstract

Sodium colistin methanesulfonate (CLM), a polypeptide antibiotic, was administered intravenously to ICR-JCL mice at dosage levels of 60, 125 and 250mg/kg/day to determine its effects on the reproductive process and fetal development. Male mice were continuously treated from day 63 prior to mating through copulation, and female mice from day 14 before mating through day 7 of gestation. Results were obtained as follows;<BR>1. CLM did not affect general behavior, body weight, food consumption, mating performance and fertility in all the treated groups of both sexes.<BR>2. CLM did not affect general behavior and food consumption in pregnant mice, but body weight gain of dams was increased in 125 and 250mg/kg groups.<BR>3. There were no significant differences between the control group and the treated groups in number of implantations, live fetuses, resorptions in the uterus and sex ratio. However, body weight of live fetuses and weight of placentas were increased in 125 and 250mg/kg groups.<BR>4. No significant increase of the prevalence of external, Visceral and skeletal anomalies of the fetuses was observed in any treated group. The progress of ossification was not affected, either.<BR>It can be concluded that CLM, at lower dosage than 60mg/kg, has no unfavorable influence on fertility and fetal development in mice.

Journal

  • CHEMOTHERAPY

    CHEMOTHERAPY 29 (9), 1044-1050, 1981

    Japanese Society of Chemotherapy

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