ANTIBACTERIAL EFFECTS OF DIDEOXYKANAMYCIN B ON GRAM NEGATIVE BACTERIA

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  • IIDA KYOKO
    Department of Microbiology, School of Dentistry, Kyushu University
  • KOIKE MASAATSU
    Department of Microbiology, School of Dentistry, Kyushu University

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Other Title
  • 新カナマイシンDKB (3', 4'-Dideoxykanamycin B) の抗菌作用
  • シン カナマイシン DKB 3 , 4 -Dideoxykanamycin B ノ コウキン サヨウ

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Abstract

Dideoxykanamycin B, a new aminoglycoside antibiotic showed the bactericidal effect on the gram-negative bacteria, as well as gentamicin. Short treatment of Escherichia coli B, Pseudomonas aeruginosa P 28 and P 29 with dideoxykanamycin B and gentamicin resulted in bleb-formation from the outer layer of the cell wall, and prolonged treatment caused lysis of the cells. These alterations may be interpreted that dideoxykanamycin B primarily acts to distort the molecular arrangement of the cell envelope.

Journal

  • CHEMOTHERAPY

    CHEMOTHERAPY 22 (5), 1037-1039, 1974

    Japanese Society of Chemotherapy

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