新しいマクロライド系抗生物質SF-837 (ミデカマイシン) に関する細菌学的評価

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タイトル別名
  • BACTERIOLOGICAL EVALUATION OF SF-837 (MYDECAMYCIN), A NEW MACROLIDE ANTIBIOTIC
  • アタラシイ マクロライドケイ コウセイブツシツ SF-837 ミデカマイシン ニ カンスル サイキンガクテキ ヒョウカ

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The bacteriological evaluation was made on SF-837, a new macrolide antibiotic developed by Research Laboratories of Meiji Seika Company, and it was proved that this substance shows almost the same antibacterial spectrum, sensitivity distribution of clinically isolated strains, cross resistance between macrolide resistant strains, effects of pH, human serum, and inoculum size on antibacterial activity as control drugs leucomycin and josamycin, as well as bactericidal effect, in vitro resistantization and cross resistance between artificial resistant strains.<BR>As to the treatment effect for mice experimental infections due to Staphylococcus and Pneumococcus, however, SF-837 was a little inferior to usual macrolide antibiotics. The difference between in vitro effect and in vivo effect of SF-837, should be investigated further pursueing the examinations on absorption, distribution, excretion and drug metabolism in mice.

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