新しいマクロライド系抗生物質SF-837 (ミデカマイシン) に関する細菌学的評価

中沢 昭三, 小野 尚子, 大槻 雅子, 小島 和子, 高田 和美, 野村 知

doi:10.11250/chemotherapy1953.21.705

新しいマクロライド系抗生物質SF-837 (ミデカマイシン) に関する細菌学的評価

DOI Web Site

中沢昭三

京都薬科大学微生物学教室
小野尚子

京都薬科大学微生物学教室
大槻雅子

京都薬科大学微生物学教室
小島和子

京都薬科大学微生物学教室
高田和美

京都薬科大学微生物学教室
野村知

京都薬科大学微生物学教室

書誌事項

タイトル別名

BACTERIOLOGICAL EVALUATION OF SF-837 (MYDECAMYCIN), A NEW MACROLIDE ANTIBIOTIC
アタラシイマクロライドケイコウセイブツシツ SF-837 ミデカマイシンニカンスルサイキンガクテキヒョウカ

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説明

The bacteriological evaluation was made on SF-837, a new macrolide antibiotic developed by Research Laboratories of Meiji Seika Company, and it was proved that this substance shows almost the same antibacterial spectrum, sensitivity distribution of clinically isolated strains, cross resistance between macrolide resistant strains, effects of pH, human serum, and inoculum size on antibacterial activity as control drugs leucomycin and josamycin, as well as bactericidal effect, in vitro resistantization and cross resistance between artificial resistant strains.<BR>As to the treatment effect for mice experimental infections due to Staphylococcus and Pneumococcus, however, SF-837 was a little inferior to usual macrolide antibiotics. The difference between in vitro effect and in vivo effect of SF-837, should be investigated further pursueing the examinations on absorption, distribution, excretion and drug metabolism in mice.