Fosfomycinに関する薬理学的研究

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書誌事項

タイトル別名
  • PHARMACOLOGICAL STUDIES ON FOSFOMYCIN
  • Fosfomycin ニ カンスル ヤクリガクテキ ケンキュウ

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説明

The pharmacological actions of fosfomycin (FOM) were investigated. The actions and minimal effective doses (MED) of FOM were summarized as follows : inhibition on the excised heart of the toad (10-3g/m1), inhibition on the excised heart of the guinea pig (10-3g/ml), bradycardia on ECG of the rabbit (20 mg/kg), stimulation on the excised intestine of the rabbit (10-4g/ml), dilation on the excised ear vessel of the rabbit (10-4g/ml), inhibition on the excised tracheal muscle of the guinea pig (2×10-3g/ml), inhibition on the excised non-pregnant uterus of the rat (10-3g/ml), no effect on the excised intestine of the guinea pig (10-3g/ml) and pregnant uterus of the rat (2×10-3 g/ml), on the permeability of abdominal skin vessel of the rabbit (1, 000μg), and on blood pressure and respiration of the rabbit (80mg/kg).<BR>These MED were much larger than minimum inhibitory concentrations and maximum blood levels in clinical uses. Therefore, it is concluded that FOM is one of the antibiotics which have less pharmacological actions.

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