Cephradineの眼科的応用のための基礎的ならびに臨床的検討

書誌事項

タイトル別名
  • OPHTHALMIC USE OF CEPHRADINE
  • Cephradine ガンカテキ オウヨウ ノ タメ ノ キソテキ ナラビニ

この論文をさがす

抄録

Laboratory and clinical experiments were performed on cephradine (CED) in ophthalmological field, and the results obtained were as follows.<BR>1. Antimicrobial activity of CED against various organisms was 50 μg/ml for Koch-Weeks bacillus, 0.2 μg/ml for Morax-Axenfeld diplobacillus, 1. 56-.6.25 μg/ml for Pneuntococcus, 0.39 pg/ml for C. diphtheriae, 0.2 μg/ml for Gonococcus, 0.39 μg/ml for Strept. hentolyticus, 50-100 μg/ml for Strept. viridans, 0.78-4.56 μg/ml for Staph. aureus and > 100 μg/ml for Ps. aeruginosa.<BR>2. The distribution of the sensitivity for 40 strains of Staph. aureus was in the range of 1.56-12.5 μg/ml, and most of them (25 strains, 62.5%) were in 3.13 μg/ml.<BR>3. The peak of serum level was attained 1 hour after oral administration of 500 mg CED, then decreased relatively quickly until 6 hours (0.1 μg/ml), and not recognized after 8 hours.<BR>4. After oral administration of 50 mg/kg in rabbit, the peak level of aqueous humor was obtained at 2 hours (1.6 μg/ml). Aqueous/serum ratio was 26.02%.<BR>The ocular tissue concentrations at 2 hours after oral application of 50 mg/kg were high in both outer and inner parts of the eye. After 4 hours, the tissue levels were scarcely recognized except lid, sclera and vitreous body.<BR>5. Clinical results<BR>1) CED capsule<BR>Oral administration of 250-500 mg CED 4 times daily revealed good effects in 22 of 28 cases, such as ulcerative blepharitis, external hordeolum, internal hordeolum, chronic dacryocystitis, marginal corneal ulcer and corneal ulcer.<BR>2) CED dry syrupBy oral application of 25-50 mg/kg/day divided 4 times, the good clinical effects were obtained in 15 of 18 cases, such as acute conjunctivitis, ulcerative blepharitis, external hordeolum, chronic dacryocystitis, marginal corneal ulcer, corneal infiltration and iridocyclitis purulenta. <BR>6. Side effects<BR>Three cases of anorexia were experienced, by cephradine capsule, and each one case of diarrhoea and soft tool by dry syrup, but no other severe side effects were noticed.

収録刊行物

詳細情報 詳細情報について

問題の指摘

ページトップへ