In vitro synergistic effect of netilmicin and cephems.
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- OTSUKI HIDEO
- Research and Development Laboratories, Essex Nippon Kabushiki Kaisha
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- KAMI HIROSHI
- Research and Development Laboratories, Essex Nippon Kabushiki Kaisha
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- SHIBAHARA TAKESHI
- Research and Development Laboratories, Essex Nippon Kabushiki Kaisha
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- OTSUKI MASAKO
- Department of Microbiology, Kyoto Pharmaceutical University
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- NISHINO TAKESHI
- Department of Microbiology, Kyoto Pharmaceutical University
Bibliographic Information
- Other Title
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- Ｎｅｔｉｌｍｉｃｉｎとセフェム系抗生物質とのｉｎ ｖｉｔｒｏ併用効果の検討
Abstract
The combined action of netilmicin (NTL) with latamoxef (LMOX), cefoperazone (CPZ), ceftizoxime (CZX), cefmenoxime (CMX) or ceftazidlme (CAZ) was studied against Escherichia coil, Serratia marcescens, Pseudomonas aeruginosa and Moraxella (Branhamella) catarrhalis. The following results were obtained<BR>1. The antibacterial activity of each antibiotic by itself against E. coil and M.(B.) catarrhaliswas strong.<BR>2. Synergistic action of NTL with each of LMOX, CPZ, CZX, CMX and CAZ was observed on all bacteria, especially S. marcescens and P. aeruginosa. The combination of NTL with CPZ was most effective.<BR>3. Bactericidal activity of NTL with LMOX or CAZ was observed on S. marcescens T-55 and P. aeruginosa E-2 at concentrations in which the respective drugs alone showed only bacteriostatic activity.<BR>4. Phase-contrast microscopic observation of P. aeruginosa E-2 demonstrated that the bacterial cells treated with LMOX or CAZ showed a filament-like form and those treated with NTL almost a normal form. In each combination lysed cells were observed.
Journal
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- CHEMOTHERAPY
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CHEMOTHERAPY 37 (2), 115-124, 1989
Japanese Society of Chemotherapy
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Keywords
Details 詳細情報について
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- CRID
- 1390001206279155200
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- NII Article ID
- 130004196702
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- ISSN
- 18845894
- 00093165
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- Text Lang
- ja
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- Data Source
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- JaLC
- CiNii Articles
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- Abstract License Flag
- Disallowed