DKBの耳鼻咽喉科領域の使用経験

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タイトル別名
  • CLINICAL EXPERIENCE WITH DKB IN OTORHINOLARYNGOLOGICAL FIELD
  • DKB ノ ジビ インコウカ リョウイキ ノ シヨウ ケイケン

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Laboratory and clinical investigations were made on a new antibiotic, 3', 4'-dideoxykanamycin B (abbr. DKB), and the following results were obtained.<BR>(1) All of 37 strains of Pseudomonas aeruginosa isolated from patients, demonstrated the DKB MIC of 0.4-1.6 mcg/ml.<BR>(2) DKB was injected intramuscularly, dripped intravenously, instillated locally or administered by nebulizer. The results obtained were effective in 10 cases, slightly effective in 1 case and ineffective in 2 cases. There experienced 1 case of remarkably effective in which the drug was dripped intravenously for the intracranial infection due to Pseudomonas aeruginosa.<BR>(3) No side effect was observed including there an auditory disorder, except Urea-N rose after DKB administration in a patient of progressed pharyngeal cancer.

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