CLINICAL EFFECTS OF L-105 ON UROLOGICAL INFECTIONS

DOI

Bibliographic Information

Other Title
  • L-105の泌尿器科領域感染症に対する臨床的検討

Abstract

L-105 is characterized by its broad antibacterial spectrum covering aerobic, anaerobic, grampositiveand gram-negative bacteria, with the stability against β-lactamases. We used the compound for the treatment of 21 patients with urinary tract infections to investigate the efficacy, safety, and usefulness.<BR>L-105 was administered to 2 patients with acute uncomplicated pyelonephritis, 15 with chronic complicated urinary tract infection, 2 with acute epididymitis, 1 with acute prostatitis, and 1 with gonorrheal urethritis.<BR>The efficacy was evaluated with the UTI Drug Evaluation Criteria as a rule.<BR>In cases of acute uncomplicated pyelonephritis L-105 efficacy was evaluated as “excellent” in 1 case and “good” in 1, the effective rate being 100%. In cases of chronic complicated urinary tract infection L-105 was evaluated “excellent” in 2, “good” in 4, and “poor” in 3, the effective rate 67%. All these cases met the UTI Criteria.<BR>Of 21 cases treated, side effects were noted in 2 cases-1 case each of anorexia, and general fatigue with fever.<BR>In view of the above study results L-105 was considered a useful compound for the treatment of urinary tract infections.

Journal

  • CHEMOTHERAPY

    CHEMOTHERAPY 34 (Supplement3), 427-434, 1986

    Japanese Society of Chemotherapy

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