THE CLINICAL EXPERIMENT OF DL-8280 IN EXTERNAL EYE DISEASES AND THE PENETRATION INTO THE TEAR OF HUMAN EYES

DOI
  • TOKUDA HISAYA
    Department of Ophthalmology, Kyorin University, School of Medicine
  • ARIMOTO KEIZO
    Department of Ophthalmology, Kyorin University, School of Medicine
  • SHIMIZU CHIHIRO
    Department of Ophthalmology, Kyorin University, School of Medicine

Bibliographic Information

Other Title
  • 眼科領域におけるDL-8280の臨床的, 実験的検討

Abstract

Eighteen cases of external eye diseases (meibomitis, dacryocystitis, orbitarsellulitis and corneal infections) were cured all after 3-10 days by DL-8280 treatment.<BR>The penetration of DL-8280 into the tear and the serum of 22 human cases were examined simultaneously at 0.25, 0.5, 1, 2, 3, 4, 6 and 8 hours after a single oral administration at a dose of 200mg. The peak of tear level was 1.36±0.32 ileml (2 hours after) and this level was considered effective to the corneal infections by S. aureus and P. aeruginosa.

Journal

  • CHEMOTHERAPY

    CHEMOTHERAPY 32 (Supplement1), 1056-1058, 1984

    Japanese Society of Chemotherapy

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