書誌事項
- タイトル別名
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- PHARMACOKINETICS OF CINOXACIN IN PATIENTS WITH IMPAIRED RENAL FUNCTION
- ジン キノウ ショウガイジ ニ オケル Cinoxacin ノ ケッセイチュウ
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抄録
The pharmacokinetics of cinoxacin, a new synthetic antibacterial agent, were examined in 6 healthy volunteers and 12 patients with different endogeneous creatinine clearances (Ccr) on the basis of a one-compartment open model. Each subject received a single 400mg oral dose of cinoxacin, and serum and urinary concentrations of free cinoxacin and cinoxacin conjugate were measured by a fluorometric method. The mean peak concentration of free cinoxacin in serum was achieved 3 hours after administration in normal subjects. The mean serum half-life of free cinoxacin was calculated for 66 minutes in normal subjects, and increased in patients along with increasing impairment of renal function. A significant correlation between the elimination rate constant and Ccr was demonstrated (p<0.001). In normal subjects, 62% of the drug was excreted in the urine as free cinoxacin within the first 12 hours, 95% as total cinoxacin including cinoxacin conjugate. The urinary excretion rate declined gradually in patients as a degree of renal impairment advanced.
収録刊行物
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- CHEMOTHERAPY
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CHEMOTHERAPY 28 (Supplement4), 133-138, 1980
公益社団法人 日本化学療法学会
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詳細情報 詳細情報について
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- CRID
- 1390001206281232896
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- NII論文ID
- 130004071499
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- NII書誌ID
- AN00186653
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- ISSN
- 18845894
- 00093165
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- NDL書誌ID
- 2221307
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- データソース種別
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- JaLC
- NDL
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可