Cefamandoleの<I>in vitro</I>抗菌作用

DOI Web Site

書誌事項

タイトル別名
  • <I>IN VITRO</I> ANTIBACTERIAL ACTIVITY OF CEFAMANDOLE
  • Cefamandole ノ in vitro コウキン サヨウ

この論文をさがす

抄録

Cefamandole is a semisynthetic cephalosporin for parenteral use. It is highly active against gram-positive and gram-negative bacteria except Pseudomonas aeruginosa. It has expanded antibacterial spectra which includes Enterobacter and indole-positive Proteus and activity equivalent to ampicillin against Haemophilus influenzae.<BR>Susceptibility of clinical isolates of pathogenic bacteria to cefamandole was measured by agar dilution method. All of the tested strains of Staphylococcus aureus and H. influenzae were inhibited at below 0.78μg/ml. At a concentration of 3.13μg/ml, over 90% of the isolates of Klebsiella pneumoniae and Proteus mirabilis, 80% of Escherichia coli and Citrobacter freandii, 70% of Enterobacter sp. and 60% of indole-positive Proteus were susceptible to cefamandole. Most isolates of Proteus vulgaris and Serratia marcescens were resistant to 100 μg/ml. The cross susceptibility of cefamandole to either cefazolin or cefoxitin revealed predominancy of the above-mentioned gram-negative pathogens which were more susceptible to cefamandole than to the others with exception of S. marcescens and P. vulgaris, to which cefoxitin is most active. A 100-fold increase in the inoculum resulted in decreased susceptibility of some organisms.<BR>Cefamandole was markedly bactericidal even at a concentration less than the agar dilution MIC; this was supported by its rapid lysis of the bacterial cells treated with this antibiotic.<BR>Cefamandole is stable to some of the p-lactamases derived from gram-negative bacteria and tends to be more resistant to hydrolysis by cephalosporinase-type than by penicillinase-type. This appears well reflected to its activity against Enterobacter and indole-positive Proteus.

収録刊行物

詳細情報 詳細情報について

問題の指摘

ページトップへ