THE CLINICAL EXPERIMENT OF BAY o 9867 (CIPROFLOXACIN) IN EXTERNAL EYE DISEASES AND THE PENETRATION INTO THE TEAR OF HUMAN EYES

DOI
  • YATA KOJI
    Department of Ophthalmology, Kyorin University, School of Medicine
  • SHIMIZU CHIHIRO
    Department of Ophthalmology, Kyorin University, School of Medicine
  • MIYAZAKI YOSHIKO
    Department of Ophthalmology, Kyorin University, School of Medicine
  • TOKUDA HISAYA
    Department of Ophthalmology, Kyorin University, School of Medicine

Bibliographic Information

Other Title
  • 眼科学領域におけるBAY o 9867 (Ciprofloxacin) の臨床的・基礎的検討

Abstract

Eighteen cases of external eye diseases (meibomitis, hordeolum) were cured all after 3-14 days by BAY o 9867 treatment.<BR>The penetration of BAY o 9867 into the tear and the serum of 11 human cases were examined simultaneously at 0.5, 1, 1.5, 2, 3, 4 and 6 hours after a single oral administration at a dose of 200 mg.The peak of tear level was 0.75±0.25μg/ml (1.5 hours after) and this level was considered effective to the external eye infections both S.aureus and P.aeruginosa.

Journal

  • CHEMOTHERAPY

    CHEMOTHERAPY 33 (Supplement7), 1022-1024, 1985

    Japanese Society of Chemotherapy

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