CS-1170による<I>Escherichia coli, Proteus morganii, Serratia mareescens</I>の形態変化について

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  • MORPHOLOGICAL ALTERATIONS IN ESCHERICHIA COLI No.29, <I>PROTEUS MORGANII</I> 101 AND <I>SERRATIA MARCESCENS</I> T-55 EXPOSED TO CS-1170
  • CS 1170 ニヨル Escherichia coli Proteus mo

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The effects of CS-1170 and cefazolin (CEZ) on the morphology of Escherichia coli No.29, Proteus morganii 101 and Serratia marcescens T-55 were examined with light microscope, phase contrast microscope and scanning electron microscope. The following results were obtained.<BR>1) Exposure of E. coli No.29 to CS-1170 revealed the formation of long filaments and spheroplastlike structures. The degree of morphological change was related to the concentrations of CS-1170 used. The filamentous forms were observed when the concentration of CS-1170 was low. Where the concentration of CS-1170 was high, the cells formed spheroplasts.<BR>It seemed that these morphological alterations of E. coil No.29 treated with CS-1170 were similar to that seen with CEZ.<BR>2) The filamentous forms, spheroplast-like structures, and cell lysis were observed when CS-1170 was allowed to act on Proteus morganii 101 and Serratia marcescens T-55 (β-lactam antibiotics resistant strains)<BR>When effected with CEZ, most cells grew similarly to untreated controls in Proteus morganii 101 and Serratia marcescens T-55.

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