MUTAGENICITY TESTS ON TMS-19-Q
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- SONO AKIRA
- Toxicological Research Laboratories, Toyo Jozo, Co., Ltd.
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- OYAIDE KIMIKO
- Toxicological Research Laboratories, Toyo Jozo, Co., Ltd.
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- KOBAYASHI YOSHIRO
- Toxicological Research Laboratories, Toyo Jozo, Co., Ltd.
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- YAMAMOTO HIROSHI
- Toxicological Research Laboratories, Toyo Jozo, Co., Ltd.
Bibliographic Information
- Other Title
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- 新マクロライド系抗生物質TMS-19-Qの変異原性
Abstract
Genetical toxicology tests on TMS-19-Q, a new macrolide antibiotic, were carried out by using microorganisms, cultured mammalian cells and small rodents.<BR>The effect of the drug on DNA damage and/or repair was examined according to the Rec-assay with Bacillus subtilis tester strains and to sister-chromatid exchange (SCE) test with cultured Chinese hamster cells.<BR>The results from these tests showed no remarkable difference in growth inhibition zones between the repair-deficient (M 45) and -proficient (H 17) tester strains, or no increase in SCE frequencies with increasing TMS-19-Q concentration; suggesting that the drug has no substantial effect on DNA damage and/or repair both in prokaryotes and eukaryotes.<BR>Further evidence for no mutagenicity of the drug was revealed by the result from the Ames microsome assay in which the drug had no effects on induction of reverse mutation.<BR>The cytogenetical effect of TMS-19-Q was examined in accordance with chromosomal aberration analysis in cultured Chinese hamster cells and with micronucleus test in mouse bone-marrow cells. Although an increase in centric fission of chromosome Nos. 10 and 11 was observed in cultured Chinese hamster cells when exposed to the drug in combination with S-9 mix., but the drug had no effect on induction of micronucleus in mice bone-marrow cells.<BR>All these results support the notion that TMS-19-Q per se is genetically safe drug.
Journal
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- CHEMOTHERAPY
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CHEMOTHERAPY 32 (Supplement6), 222-227, 1984
Japanese Society of Chemotherapy
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Details 詳細情報について
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- CRID
- 1390001206281662208
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- NII Article ID
- 130004194580
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- ISSN
- 18845894
- 00093165
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- Data Source
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- JaLC
- CiNii Articles
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- Abstract License Flag
- Disallowed