書誌事項
- タイトル別名
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- LABORATORY AND CLINICAL STUDIES ON MEZLOCILLIN
- Mezlocillin ニ カンスル キソテキ ケントウ ト コキュウキ カン
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抄録
The laboratory and clinical studies on mezlocillin, a new semisynthetic penicillin, were performed with following results.<BR>1. Minimal Inhibitory Concentration (MIC) of mezlocillin against 79 strains of H. influenzae, isolated from patients with respiratory tract infections, were 0.025μg/ml (1 strain), 0.05μg/ml (25 strains), 0.1μg/ml (34 strains) and 0.2μg/ml (19 strains).<BR>The antibacterial activity of mezlocillin was from 2 to 4 times stronger than that of ampiciilin (ABPC), carbenicillin, or sulbenicillin.<BR>2. Influence of inoculum size of bacteria were studied on the β-lactamase producing, ABPC resistant strains of H. influenzae (5 strains) and H. parainfluenzae (1 strain).<BR>Mezlocillin was inactivated as well as ABPC with β-lactamase.<BR>3. Tissue concentrations in rats reached peak values at 15 minutes and they were the following order of serum, liver, kidney and lung. 2 hours later, mezlocillin was not detectable in all organs.<BR>4. Eight infections (chronic bronchitis 6, bronchoectasis 2) of 6 patients were treated with mezlocillin, which was effective in all cases.<BR>The causal organisms of the respiratory tract infections were H. influenzae in 5 cases, Streptococcus pneumoniae in 1 case and mixed infection in 2 cases.<BR>5. No side effects due to administration of this drug were noted in any of the cases.
収録刊行物
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- CHEMOTHERAPY
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CHEMOTHERAPY 27 (Supplement1), 212-218, 1979
公益社団法人 日本化学療法学会
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詳細情報 詳細情報について
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- CRID
- 1390001206281744128
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- NII論文ID
- 130004192531
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- NII書誌ID
- AN00186653
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- ISSN
- 18845894
- 00093165
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- NDL書誌ID
- 2077910
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- データソース種別
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- JaLC
- NDL
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可