Mezlocillinに関する臨床的研究

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タイトル別名
  • CLINICAL STUDIES ON MEZLOCILLIN
  • Mezlocillin ニ カンスル リンショウテキ ケンキュウ

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Mezlocillin has been studied clinically, and the following results were obtained.<BR>1. Mezlocillin was injected at a dose of 2g to the patients with various renal function, and the blood concentrations were determined.<BR>In a patient with a creatinine clearance of 72.0 ml/min, the serum concentration reached the peak of 150μg/ml at one hour after administration and fell down rapidly to an undetectable level after 8 hours.<BR>In patients with creatinine clearance of 18.5ml/min and 7.3 ml/min, serum concentrations were rather higher than in patients with hemodialysis and the serum halflife was prolonged.<BR>The fall in the serum concentration was observed during 5 hour hemodialysis in two patients with renal insufficiency.<BR>2. Mezlocillin administered to 10 patients with respiratory tract infections (9 cases) and biliary tract infection (1 case) was effective in 4 and not effective in 6 patients.<BR>3. In one case severe anemia was observed, but in another cases no particular side effects caused by mezlocillin administration were observed.

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