HBKの筋注時および点滴静注時における臨床的効果と基礎的検討

Antimicrobial activities against urinary bacteria, serum levels, urinary recovery and clinical efficacies on complicated urinary tract infections of HBK, a new aminoglycoside antibiotic, were studied.<BR>The results were summarized as follows;<BR>1) MICs of HBK for 18-reference strains, 100 ampicillin resistant E. coli, 28 S. marcescens and 50 P. aeruginosa which were isolated from urinary tract infections were found to be generally equal to those of gentamicin, but superior to those of amikacin.<BR>2) An average of peak serum level of HBK was 5.77μg/ml at 0.5-1 hours after intramuscular administration (100 mg) in healthy two volunteers.<BR>Urinary recovery rate for 6 hours averaged about 60%.<BR>3) Twelve patients with complicated urinary tract infections were treated with intramuscular administration of HBK at the dose of 100 mg twice a day for 5 days.<BR>As to overall clinical efficacies of those patients, moderate response was seen only in 1 patient and poor response in 11 patients. The overall effectiveness rate became 8%.<BR>The unexpected results seemed to be due to unsuitable patients with complicated type of infection.<BR>4) Ten patients with complicated urinary tract infections were treated with drip-infusion of HBK (100 mg × 2/day). Overall clinical efficacies of studies were excellent in 4, moderate in 1 and poor in 5 patients, the overall effectiveness rate being 50%.<BR>5) Side effects were evaluated in all 23 patients. Mild diarrhea was seen in 1 patient, and moderate and transient elevation of GOT, GPT and Al-pase were obsered respectivery 2, 1 and 1 patient.<BR>HBK was considered to be useful and safe new aminoglycoside in the treatment of complicated urinary tract infections.