泌尿器科領域におけるHBKの基礎的臨床的検討
書誌事項
- タイトル別名
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- FUNDAMENTAL AND CLINICAL STUDIES ON HBK IN UROLOGICAL FILED
抄録
HBK was developed as a useful antibiotic for bacteria resistant to other aminoglycoside antibiotics.<BR>Fundamental study: From results of absorption and excretion (100 mg intramuscular administration) in healthy volunteers, the average-of penk serum level of HBK was 9.00μg/ml (15 min. after injection), AMK was 6.71μg/ml (30 min. after injection) and T1/2s were 2.09 and 1.44 hr. respectively. Fifty per-cent and over of HBK and AMK were excreted in urine within the first 4 hours, and the urinary recovery rates within the first 24 hours were 74.6, 84.3% respectively.<BR>Clinical study: 18 patients with complicated urinary tract, infections and 3 patients with other infections were treated with intramuscular administration or 1 hour drip-infusion of HBK at the dose of 100-200 mg for 5-7 days. The clinical results of 12 cases were assessed by; UTI Drug Efficacy Evaluation Criteria. The results were rated as excellent in 1 case, good in 3 cases and poor in 8 cases with an efficacy rate of 33%. Bacteriologically, 11 out of 19 (58;sv) strains were eradicated. Six out of 12 mixed infections were rated as good in only 1 case and poor in other 5 cases, so the efficacy rate became lower. As to the case with acute prostatitis, acute uncomplicated pyelonephritis and acute epididymitis, the Doctor's evaluation was “excellent” in all 3 cases.<BR>No side effect was observed in these 21 cases and abnormal laboratory findings such as a slight elevations of S-GOT and S-GPT, S-GOT, S-GPT and Al-P in one case each were observed after treatment.<BR>From these results it is suggested that is a safe AGs and useful for moderate infections of the field of urology.
収録刊行物
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- CHEMOTHERAPY
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CHEMOTHERAPY 34 (Supplement1), 391-402, 1986
公益社団法人 日本化学療法学会
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詳細情報 詳細情報について
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- CRID
- 1390001206281870208
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- NII論文ID
- 130004072403
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- ISSN
- 18845894
- 00093165
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- データソース種別
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- JaLC
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可