Cephacetrileの基礎的研究

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タイトル別名
  • BASIC STUDIES ON CEPHACETRILE
  • Cephacetrile ノ キソテキ ケンキュウ

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The basic and bacteriological studies on Cephacetrile (CEC) were performed in comparison with the other cephalosporin derivatives, and the following results were obtained.<BR>1) The sensitivities of 94% of test strains of Staph. aureus were below 0.78 μg/ml. Mean MIC of CEC tends to be greater than that of CET, CER, smaller than CEG and CEX.<BR>The MIC of 64% of test strains of E. coli was 12.5 μg/ml, 27% was 25 μg/ml and 9% was 100 μg/ml, and these sensitivity pattern were similar to that of CET.<BR>The sensitivities of 93% of test strains of Klebsiella were below 12.5 μg/ml. The sensitivities of 92% of test strains of Enterobacter cloacae were above 100 μg/ml, and nearly the same as CET, CER, CEG and CEX.<BR>The sensitivities of 5 strains of Proteus mirabilis were 25 μg/ml, mean MIC of CEC tends to be greater than CET, and nearly the same as CER and CEG.<BR>The sensitivity distribution curve of Vibrio parahaemolyticus showed similar pattern as that of CET, CER and CEG. The sensitivities of Proteus inconstans, Proteus rettgeri, Proteus morganii and Pseud. aeruginosa were above 100 μg/ml, and the same as other cephalosporin derivatives.<BR>2) Cross resistance was observed between CEC and other cephalosporin derivatives.<BR>3) The changes in inoculum size of Staph. aureus did not show any influence on antibacterial activity of CEC. The antibacterial activity of CEC to E. coli showed definite increase with the decrease in inoculum size.<BR>4) The antibacterial activity of CEC to Staph. aureus and E. coli showed to be more potent at the acid side, and to be less potent at the alkaline side of culture medium pH.<BR>5) CEC showed a considerably high bactericidal action against Staph. aureus and E.coli.<BR>6) The antibacterial activity of CEC showed a remarkably decrease in the alkaline solution.<BR>7) CEC solution showed red colorization in the neutral, and yellow in the alkaline side, but none in the acid at 37-40°C.<BR>8) In the colored substance which was extracted by butanol from the colored solution of CEC, two spots of pink and violet color were observed on the plate of TLC.

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