PHARMACOKINETICS OF CEPHALOTHIN IN PATIENTS WITH IMPAIRED RENAL FUNCTION. I

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  • OHKAWA MITSUO
    Department of Urology, School of Medicine, Kanazawa University
  • ORITO MATSUO
    Department of Urology, School of Medicine, Kanazawa University
  • SUGATA TOSHIAKI
    Department of Urology, School of Medicine, Kanazawa University
  • SAWAKI MASARU
    Department of Urology, School of Medicine, Kanazawa University
  • OKASHO AKIRA
    Department of Urology, School of Medicine, Kanazawa University
  • NAKASHITA EINOSUKE
    Department of Urology, School of Medicine, Kanazawa University
  • KURODA KYOICHI
    Department of Urology, School of Medicine, Kanazawa University
  • FUNADA HISASHI
    Department of Internal Medicine (III), School of Medicine, Kanazawa University

Bibliographic Information

Other Title
  • 機能障害腎における抗生剤 (CET) の動態について.I
  • キノウ ショウガイ ジン ニ オケル コウセイザイ CET ノ ドウタイ ニ
  • Correlation between Renal Function and Urinary Excretion
  • 腎機能と排泄動態

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Abstract

The pharmacokinetics of cephalothin (CET) was studied to investigate the correlation mainly between renal function (creatinine clearance and PSP) and urinary excretion in 4 normal men, 3 patients of renal insufficiency and 10 patients collectable split urine samples. Serum level and urinary excretion were assayed serially after drip infusion of 2.0 g of CET for 1 hour. Assays of the antibiotic concentration in serum and urine were carried out by the cup plate method with Bacillus subtilis ATCC 6633 as the test organism.<BR>The results obtained were as follows : <BR>1. A significant increase of serum level was noted in the case of renal insufficiency in comparison with the subjects with normal renal function, while the considerable decrease of urinary excretion was observed in the cases of renal insufficiency.<BR>2. The split renal function of the 10 patients significantly correlated with their urinary excretion of CET. And the normal kidney could compensate the impaired kidney in urinary excretion of CET.<BR>3. The total renal function in 16 cases also significantly correlated with the total urinary excretion of CET.

Journal

  • CHEMOTHERAPY

    CHEMOTHERAPY 24 (3), 498-505, 1976

    Japanese Society of Chemotherapy

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