マウス実験的局所感染症に対するCefixime (CFIX) の治療効果について
書誌事項
- タイトル別名
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- THERAPEUTIC EFFICACY OF CEFIXIME AGAINST EXPERIMENTAL LOCAL INFECTIONS IN MICE
抄録
The therapeutic efficacies of cefixime (CFIX) were evaluated in models of local infections in mice and compared with those of cephalexin (CEX) and cefaclor (CCL), and following results were obtained.<BR>In experimental pulmonary infection with Klebsiella pneumoniae DT-S in mice, CFIX demonstrated superior efficacy to CEX and CCL and also showed strong bactericidal action and inhibitory activity of regrowth. In experimental urinary tract and uterus infections with Escherichia coli 444, K. pneumoniae KC-1, and Serratia marcescens T-55 in mice, the efficacy of CFIX was superior to that of CEX and CCL. CFIX showed high peak and prolonged serum levels in normal mice following oral administration. The peak serum concentration of CFIX was lower than that of CEX, but comparable to that of CCL. CFIX had longer half life than that of CEX and CCL.
収録刊行物
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- CHEMOTHERAPY
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CHEMOTHERAPY 33 (Supplement6), 97-102, 1985
公益社団法人 日本化学療法学会
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詳細情報 詳細情報について
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- CRID
- 1390001206282527616
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- NII論文ID
- 130004072326
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- ISSN
- 18845894
- 00093165
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- データソース種別
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- JaLC
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可