マウス実験的局所感染症に対するCefixime (CFIX) の治療効果について

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  • THERAPEUTIC EFFICACY OF CEFIXIME AGAINST EXPERIMENTAL LOCAL INFECTIONS IN MICE

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The therapeutic efficacies of cefixime (CFIX) were evaluated in models of local infections in mice and compared with those of cephalexin (CEX) and cefaclor (CCL), and following results were obtained.<BR>In experimental pulmonary infection with Klebsiella pneumoniae DT-S in mice, CFIX demonstrated superior efficacy to CEX and CCL and also showed strong bactericidal action and inhibitory activity of regrowth. In experimental urinary tract and uterus infections with Escherichia coli 444, K. pneumoniae KC-1, and Serratia marcescens T-55 in mice, the efficacy of CFIX was superior to that of CEX and CCL. CFIX showed high peak and prolonged serum levels in normal mice following oral administration. The peak serum concentration of CFIX was lower than that of CEX, but comparable to that of CCL. CFIX had longer half life than that of CEX and CCL.

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