<I>IN VITRO</I> AND <I>IN VIVO</I> ANTIBACTERIAL ACTIVITY OF T-1220

DOI Web Site 1 Citations
  • UEO KENJI
    Department of Microbiology, School of Medicine Gunma University
  • TAI MASARU
    Department of Microbiology, School of Medicine Gunma University
  • HAYASHI TOSHIO
    Department of Microbiology, School of Medicine Gunma University
  • FUKUOKA YOSHIKAZU
    Department of Microbiology, School of Medicine Gunma University
  • MITSUHASHI Susumu
    Department of Microbiology, School of Medicine Gunma University

Bibliographic Information

Other Title
  • T-1220の<I>in vitro</I>および<I>in vivo</I>抗菌作用について
  • T 1220 ノ in vitro オヨビ in vivo コウキン サヨウ

Search this article

Description

A synthetic penicillin, T-1220, is a derivative of aminobenzylpenicillin. In vitro and in vivo antibacterial activities of T-1220, ampicillin (ABPC) and carbenicillin (CBPC) were compared against gram-positive and gram-negative bacteria which were isolated from clinical specimens. The results were summarized as follows : <BR>1) T-1220, ABPC and CBPC exhibited almost similar effectiveness against grampositive bacteria.<BR>2) In vitro antibacterial activities against gram-negative bacteria were compared using about 100-300 clinical isolates of each species of bacteria including E. coli, K. pneumoniae, Proteus group, S. marcescence, E. cloacae and P. aeruginosa. T-1220 was found to be more effective than ABPC and CBPC, particularly against P. aeruginosa, K. pneumoniae, Proteus group and S. marcescence.<BR>3) Antibacterial activity of T-1220 was not affected by the changes of pH and media. Addition of human serum to culture media did not show any big effect on the antibacterial activity of T-1220.<BR>4) Greater bactericidal activity was demonstrated with T-1220; minimum bactericidal concentration (MBC) toward various strains of gram-negative rod bacteria was almost the same as their minimum inhibitory concentration (MIC) values and was less than the MBCs of ABPC and CBPC.<BR>5) The 50 percent inhibition dose (ID50) of T-1220 was found to be much less than that of CBPC.<BR>6) T-1220 as well as penicillin G was hydrolyzed by penicillinase (PCase). But T-1220 was very stable than CBPC against PCase derived from P. aeruginosa. Cephalosporinase (CSase) did not hydrolize T-1220, CBPC and ABPC.<BR>7) In vivo antibacterial activities of T-1220, ABPC and CBPC were compared using the systemic infections of mice with P. aeruginosa, K. pneumoniae and E. coli. The ED50 values (mg/kg) of T-1220 were consistently less than those of ABPC and CBPC.

Journal

  • CHEMOTHERAPY

    CHEMOTHERAPY 25 (5), 700-709, 1977

    Japanese Society of Chemotherapy

Citations (1)*help

See more

Details 詳細情報について

Report a problem

Back to top