広域合成ペニシリンT-1220の<I>in vitro</I>抗菌作用と, グラム陰性桿菌のマウス実験感染における治療効果について

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  • ON THE <I>IN VITRO</I> ANTIBACTERIAL ACTIVITY OF T-1220, BROAD-SPECTRUM PENICILLIN, AND THERAPEUTIC EFFECT ON EXPERIMENTAL INFECTION IN MICE WITH GRAM-NEGATIVE BACILLI
  • コウイキ ゴウセイ ペニシリン T 1220 ノ in vitro コウキン

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A study of the bactericidal effect of broad-spectrum Penicillin T-1220 in vitro and in vivo showed a wide bactericidal spectrum and an in vitro bactericidal effect for bacteria strains resistant to conventional penicillin.<BR>The in vivo results showed that a challenge with a small inoculum was more effective than CBPC and SBPC against Serratia and equally effective against P. aeruginosa and E. coli. The therapeutic effect of a challenge with a large inoculum, however, was not as marked as that of a challenge with a small inoculum.

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