ANTIBACTERIAL ACTIVITIES OF T-1220 AGAINST CLINICALLY ISOLATED BACTERIA

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  • KOIKE MASAATSU
    Department of Microbiology, School of Dentistry, Kyushu University
  • NAGAYAMA ARIAKI
    Department of Microbiology, School of Dentistry, Kyushu University
  • IIDA KYOKO
    Department of Microbiology, School of Dentistry, Kyushu University
  • MIYAZAKI YUSUKE
    Department of Microbiology, School of Dentistry, Kyushu University

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Other Title
  • 臨床分離菌に対するT-1220 の抗菌作用
  • リンショウ ブンリキン ニ タイスル T 1220 ノ コウキン サヨウ

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Abstract

Antibacterial activities of T-1220 against clinically isolated bacteria, 107 strains of Escherichia coli, 28 strains of Klebsiella pneumoniae, 11 strains of Proteus and 87 strains of Pseudomonas aeruginosa, were examined by the twofold agar-dilution method, using Difco Heart Infusion Agar. Minimal inhibitory concentrations (MIC) of this drug were mainly distributed from 0.39 μg/ml to 6.25 μg/ml. Further, the sensitivities of these strains were compared with T-1220 and other penicillins, aminobenzylpenicillin (ABPC), carbenicillin (CBPC) and cephalexin (CEX). Almost of these isolated strains of E. coli were sensitive to these drugs. However, MIC of T-1220 was the lowest among these drugs. All of the strains of Pseud. aeruginosa were resistant to ABPC, C13PC and CEX, but 82% of these strains were highly sensitive to T-1220.

Journal

  • CHEMOTHERAPY

    CHEMOTHERAPY 25 (5), 765-768, 1977

    Japanese Society of Chemotherapy

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