PTC-Dによる閉塞性黄疸解除時の抗生物質胆汁中移行 SulbenicillinおよびCefazolinについて

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タイトル別名
  • THE BILIARY EXCRETION OF SULBENICILLIN AND CEFAZOLIN IN CASES OF OBSTRUCTIVE JAUNDICE WITH PTC-DRAINAGE
  • PTC - D ニヨル ヘイソクセイ オウダン カイジョジ ノ コウセイ ブッ

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抄録

In this paper, the biliary excretion of SBPC and CEZ was clinically studied in 15 patients with obstructive jaundice after Percutaneous Transhepatic Cholangio-Drainage (PTC-D).<BR>The sertm and bile levels were determined at daily intervals after one-hour intravenous infusion of the antibiotics.<BR>The excretion rate was expressed as percent of the rate of peak levels of serum and those of bile.<BR>The biliary excretion of the antibiotics showed a certain change at time intervals which was not correlated to kinds and dose of the antibiotics administered. Starting at day 4 after PTC-D, there was a period of about 3 weeks during which biliary excretion rate was decreased remarkably. These results would be valuable for the chemotherapy of patients with the biliary tract obstruction.

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