STUDIES ON PIVMECILLINAM THERAPY IN URINARY TRACT INFECTIONS

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Other Title
  • 尿路感染症に対するPivmecillinamの検討
  • ニョウロ カンセンショウ ニ タイスル Pivmecillinam ノ ケント

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1) Minimal inhibitory concentration of mecillinam were determined in 94 strains isolated from urinary tract infections by the plate dilution method. In 108 inoculum size, 10 strains of E. coli (30 strains) were inhibited at 12.5μg/ml or less. Most strains of other species were resistant to 100μg/ml of mecillinam.In 106 ineculum size, 24 strains of E. coli were inhibited at 0.39μg/ml or less. Antibacterial activities of mecillinam against clinically isolated E. coli were rather stronger than ampicillin. Those against clinically isolated Proteus mirabilis and Staphylococcus aureus were rather weak than ampicillin.<BR>2) In one case with normal renal function, the blood level reached to the maximum (1.7μ9/ml) at 1 hour after oral administration of pivmecillinam 200mg, decreased rapidly thereafter, and the urinary recovery rate was 35.1% within 6 hours.<BR>3) Sixty-eight cases with urinary tract infections were treated with pivmecillinam at oral doses of 150-400mg per day. Excellent or good results were obtained in 59 cases.<BR>4) Gastrointestinal symptom was observed in 3 cases and slight elevation of GPT on laboratory findings in 1 case throughout this series.

Journal

  • CHEMOTHERAPY

    CHEMOTHERAPY 25 (1), 273-283, 1977

    Japanese Society of Chemotherapy

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