Ticarcillin (TIPC) の緑膿菌尿路感染症に対する臨床的ならびに基礎的研究

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  • CLINICAL AND BASIC STUDY ON TICARCILLIN (TIPC) IN URINARY TRACT INFECTION CAUSED BY <I>PS. AERUGINOSA</I>
  • Ticarcillin TIPC ノ リョクノウキン ニョウロ カンセンショウ

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1) The MIC was studied on 26 Ps. aeruginosa strains isolated from the 26 in-patients, and the MIC of ticarcillin was similar to sulbenicillin and better than carbenicllin.<BR>2) Ticarcillin was intravenously administered at a dose of 1.0g to the 8 patients or urinary recovery study. The average of urinary recovery rate on ticarcillin was 52.3% and the mean urinary recovery concentration was 1, 094 μg/ml within 0-6 hours and a high urinary concentration was kept over 6 hours.<BR>3) Clinical evaluation on 20 patients with urinary tract infection caused by Ps. aeruginosa was 70% on effectiveness by administering ticarcillin 1.0-3.0 g/day for 7 days.<BR>4) No side effect occurred excluding elevation of GOT, GPT in one case of this ticarcillin treatment.

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