Ticarcillinに関する研究

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タイトル別名
  • STUDIES ON TICARCILLIN
  • Ticarcillin ニカンスルケンキュウ

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On a new semisynthetic penicillin, ticarcillin, some basic and clinical investigations were performed, and the following results were obtained.<BR>1. The sensitivity of various gram-negative bacilli of clinical isolates against ticarcillin exceeded that of carbenicillin in a majority of strains. However, there found cross resistance between the sensitivity of ticarcillin and carbenicillin.<BR>2. The serum levels and urinary excretion were measured following ticarcillin 3g administration by drip infusion to six healthy volunteers. The serum levels and urinary excretion following intravenous administration of 1g of ticarcillin and sulbenicillin to six healthy volunteers by cross over method were compared. The both values of ticarcillin somewhat exceeded those of sulbenicillin.<BR>3. The serum, biliary and urinary levels of ticarcillin following intramuscular injection to CCl4-treated rats were compared with those of controls. There was no fixed tendency in serum and biliary levels, but the difference was found among urinary excretions.<BR>4. Clinically, a total of five cases with a total of nine infection sites was treated with ticarcillin. As a result, three were effective, one was fair, and five were poor. No side effect was found.

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