Ticarcillinにかんする臨床的研究

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タイトル別名
  • CLINICAL STUDIES ON TICARCILLIN
  • Ticarcillin ニ カンスル リンショウテキ ケンキュウ

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1) Clinical pharmacological studies of ticarcillin were conducted in patients with impaired renal function.The ticarcillin concentrations in the serum of patients 1, 2, 4, 6, 24 hours after an intravenous injection of 1 g are shown in Table 1 and Fig. 1. Serum half-lives of ticarcillin are about 2 hours (Ccr. 74 ml/min.), 4. 5 hours (Ccr. 26 ml/min.), 13 hours (Ccr. less than 5 ml/min.) and 4-7 hours (Ccr. less than 5 ml/min., during hemodialysis), <BR>2) Ticarcillin was used in 12 cases. Results are shown in Table 2 and 3. Two cases (Case 3, 5) were proven not to be infectious disease, and they were excluded from the effect evaluation. Clinical effects were good in 7 cases, fair in 1 case and poor in 2 cases. No distinct side effects were observed.

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