ペニシリン系抗生物質Ticarcillinにかんする基礎的研究ならびに呼吸器感染症への応用

DOI Web Site

書誌事項

タイトル別名
  • BASIC STUDY ON TICARCILLIN AND ITS APPLICATION TO PULMONARY INFECTIOUS DISEASES
  • ペニシリンケイ コウセイ ブッシツ Ticarcillin ニ カンスル キソ

この論文をさがす

抄録

A new semi-synthetic penicillin, ticarcillin (TIPC) was investigated in laboratory and clinical field and the followings were obtained.<BR>1) Antibacterial activity<BR>Minimal inhibitory concentration of TIPC was compared with that of carbenicilln (CBPC). As the result, the antibacterial activity of TIPC was parallel with that of CBPC. But, in Ps. aeruginosa, E. coli, Salmonella and Enterobacter aerogenes strains TIPC showed better antibacterial activity than CBPC.<BR>2) Concentration in serum and sputum<BR>The peak of serum concentration was 140.0 and 250. 0 μ/ml respectively following 3.0 g and 6. 0 g drip infusion of TIPC. The half life was 0. 72-0. 78 hour. The peak of the concentration in sputum was 0.7 μg/ml following 6. 0 g drip infusion. And the ratio of serum concentration to sputum one was 0.003.<BR>3) Clinical evaluation in respiratory infections<BR>TIPC was administered to 5 chronic pulmonary infections caused by Ps. aeruginosa and one bronchopneumonia. The daily dose was 3. 0 to 6. 0 g and duration 4 to 22 days. As the results, clinical response was excellent in one, good in 2, fair in one and poor in 2 cases. Ps. aeruginosa in sputum was disappeared in one case. No side effects nor abnormal laboratory findings were observed.

収録刊行物

詳細情報 詳細情報について

問題の指摘

ページトップへ