小児科領域における新注射用半合成ペニシリンTicarcillin (TIPC) にかんする基礎的, 臨床的研究

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  • BASIC AND CLINICAL STUDIES ON NEW INJECTABLE SEMISYNTHETIC PENICILLIN, TICARCILLIN (TIPC) IN PEDIATRIC FIELD
  • ショウニカ リョウイキ ニ オケル シン チュウシャヨウ ハン ゴウセイ ペニ

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Ticarcillin (TIPC) was intravenously administrated to the 27 pediatric patients and the follwing basic and clinical results were obtained.<BR>1. TIPC was administrated about 30. 0-50. 0 mg/kg (body weight) intravenously. The serum concentration peak of TIPC was at the end of administration (one shot and drip infusion), and its high concentration was kept over 1 hour and higher than that of sulbenicillin.<BR>2. Urinary excretion rate was about 85% in active state within 6 hours.<BR>3. On two whooping cough cases TIPC was administrated at a dose of 160 mg/kg/day for 7-10 days, on 3 acute bronchitis, 3 measles pneumonia, 9 bronchopneumonia and 3 other cases 60-140 mg/ kg / day for 3-8 days. Excluding 1 mumps, 1 meningitis and 3 mycoplasmal pneumonia cases, good clinical response was obtained.<BR>4. On purulent tympanitis case isolated Ps. aeruginosa, TIPC was administrated at a dose of 200mg/ kg / day for 8 days and clinical effectiveness was obtained.<BR>Also, on sepsis isolated Klebsiella accompanied leukemia, TIPC was administrated at a dose of 400 mg /kg / day with GM. As a result, the patient was cured.<BR>5. No abnormal finding was observed in renal and liver function after administration of TIPC.<BR>6. Clinical good response was observed in 23 cases excluding 4 cases.

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