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- SEKINE OSAMU
- Department of Internal Medicine, Shinrakuen Hospital
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- USUDA YOSHIMARU
- Department of Internal Medicine, Shinrakuen Hospital
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- AOKI NOBUKI
- Department of Internal Medicine, Shinrakuen Hospital
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- WAKABAYASHI NOBUHITO
- Department of Pharmacy, Shinrakuen Hospital
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- HAYASHI SEIICHI
- Department of Pharmacy, Shinrakuen Hospital
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- WATANABE KYOKO
- Laboratories, Shinrakuen Hospital
Bibliographic Information
- Other Title
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- KW-1062に関する臨床的研究
- KW 1062 ニ カンスル リンショウテキ ケンキュウ
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Abstract
KW-1062 is a new aminoglycoside antibiotic with potent antimicrobial activity against gram-negative bacteria.<BR>1. After a single intramusclar injection of 40 mg of KW-1062 to patients with impaired renal functions, serum levels were determined. In a patient with a creatinine clearance of 36 ml/min, the serum concentration reached to the peak after 2 hrs and fell down slowly to an undetectable level after 24 hrs. In patients with more severe renal insufficiency (Ccr. 0 and 8ml/min), however, the serum levels of KW-1062 after 24 hrs were still about a half of the peak levels. The fall in the serum concentration was observed during 5-hr haemodialysis in a patient with renal insufficiency.<BR>2. KW-1062 was administered to 13 patients with respiratory tract infections (10 cases) and urinary tract infections (3 cases including a patient with renal insufficiency) and found to be effective in 11, fairly effective in one and non-effective in one. No significant adverse reactions were encountered.
Journal
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- CHEMOTHERAPY
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CHEMOTHERAPY 25 (7), 1952-1957, 1977
Japanese Society of Chemotherapy
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Details 詳細情報について
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- CRID
- 1390001206283531136
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- NII Article ID
- 130004071042
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- NII Book ID
- AN00186653
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- ISSN
- 18845894
- 00093165
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- NDL BIB ID
- 1842324
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- Data Source
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- JaLC
- NDL
- CiNii Articles
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- Abstract License Flag
- Disallowed