EXPERIMENTAL STUDIES ON ADMINISTRATION OF CHEMOTHERAPEUTIC AGENTS

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Other Title
  • 化学療法剤の投与法にかんする実験的解析
  • カガク リョウホウザイ ノ トウヨホウ ニ カンスル ジッケンテキ カイセキ
  • VI. EFFECT OF TICARCILLIN AGAINST <I>PSEUDOMONAS AERUGINOSA</I>
  • 6. 緑膿菌に対するTicarcillinの効果

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Abstract

The most effective administration of a semisynthetic penicillin, ticarcillin (TIPC), has been studied in the experimental mice infection with Pseudomonas aeruginosa.<BR>1) Pseudomonas aeruginosa damaged by TIPC or carbenicillin (CBPC), when the drug was free, immediately began to regrow in vitro.<BR>2) The therapeutic efficacy of TIPC on multiple administrations was more effective than that of CBPC.<BR>3) An important factor to decide the therapeutic efficacy of TIPC and CBPC was the total duration of the effective concentration rather than the total dosing amounts of the drug.

Journal

  • CHEMOTHERAPY

    CHEMOTHERAPY 25 (9), 2422-2427, 1977

    Japanese Society of Chemotherapy

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