LABORATORY STUDIES ON ANTIBACTERIAL ACTIVITY OF TICARCILLIN AGAINST GRAM NEGATIVE BACILLI

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  • TOMIOKA SUSUMU
    Department of Internal Medicine and Central Laboratories, Keio University, School of Medicine
  • KOBAYASHI YOSHIO
    Department of Internal Medicine and Central Laboratories, Keio University, School of Medicine

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Other Title
  • Ticarcillinのグラム陰性桿菌に対する基礎的検討
  • Ticarcillin ノ グラム インセイ カンキン ニ タイスル キソテキ

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Abstract

Ticarcillin, a new semisynthetic penicillin, was investigated on the antibacterial activity chiefly against gram-negative bacilli as Ps. aeruginosa derived from blood, and on the combination effect with aminoglycoside antibiotics to compare carbenicillin and sulbenicillin. Results obtained were as follows.<BR>1. Ticarcillin showed stronger antibacterial activity than carbenicillin and sulbenicillin against all species of Ps. aeruginosa, Enterobacter and Serratia.<BR>2. Ticarcillin and gentamicin or dibekacin were found to be synergistically bacteriostatic against all strains of Ps. aeruginosa, the effect being 8-16 times stronger compared with a single administration. Compared with sulbenicillin, ticarcillin was shown to inhibit the growth of Ps. aeruginosa equally to sulbenicillin with 1/2 concentration of sulbenicillin, if concentration of gentamicin was fixed.

Journal

  • CHEMOTHERAPY

    CHEMOTHERAPY 25 (9), 2463-2470, 1977

    Japanese Society of Chemotherapy

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