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- MATSUU YOSHIFUMI
- Department of Ophthalmology, Nagasaki University, School of Medicine
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- MISHIMA KEIICHIRO
- Department of Ophthalmology, Nagasaki University, School of Medicine
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- NAKAMURA SHINSAKU
- Department of Ophthalmology, Nagasaki University, School of Medicine
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- TAKAKU ISAO
- Department of Ophthalmology, Nagasaki University, School of Medicine
Bibliographic Information
- Other Title
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- KW-1062の眼科領域における基礎的ならびに臨床的検討
- KW 1062 ノ ガンカ リョウイキ ニ オケル キソテキ ナラビニ リンシ
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Abstract
1) The intramuscular administration of KW-1062 to mature rabbit at a dose of 10 mg/kg resulted in a peak serum concentration of 50. 8 gg/m1 at 30 minutes after dosing and in a peak aqueous humor concentration of 3.6 μg/ml at 1 hour after dosing.<BR>2) The subconjunctival administration of KW-1062 to mature rabbit at a dose of 15 mg (about 0.4 ml) resulted in a peak serum concentration of 30.6 μg/ml and a peak aqueous humor concentration of 19.8 μg/ml at 30 minutes after dosing. Even at 4 hours after dosing, relatively high aqueous humor cocentration of 10.3 μg/ml was observed.<BR>3) KW-1062 was injected intramuscularly to adult patients of cataract and glaucoma 1-3 hours before operation at a dose of 40 mg : most of their aqueous humor concentration were trace.<BR>4) KW-1062 was administrated to 11 patients consisting of blepharitis, phlegmone palpebrae, dacryocystitis and ulcus corneae serpens. Clinical response was good in 10 out of 11 patients, effectiveness rate being 90.9%.<BR>5) No serious side effects were observed except one case, of whom conjunctival bulbi changed degenerative after subconjunctival injection of KW-1062 (10 mg, 0.25 ml) for 10 days, but this change was reversible.
Journal
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- CHEMOTHERAPY
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CHEMOTHERAPY 25 (7), 2288-2291, 1977
Japanese Society of Chemotherapy
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Details 詳細情報について
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- CRID
- 1390001206283954048
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- NII Article ID
- 130004071098
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- NII Book ID
- AN00186653
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- ISSN
- 18845894
- 00093165
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- NDL BIB ID
- 1842381
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- Data Source
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- JaLC
- NDL
- CiNii Articles
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- Abstract License Flag
- Disallowed