複雑性尿路感染症に対するSulbactam・Ampicminの使用経験

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  • SULBACTAM·AMPICILLIN IN PATIENTS WITH COMPLICATED URINARY TRACT INFECTION

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Sulbactam·Ampicillin (SBT·ABPC) was administered intravenously at a dose of 1.5g twice a day to 34 patients with complicated urinary tract infection and the therapeutic efficacy of the drug and safety were evaluated. The results were summarized as follows.<BR>1) Clinical effect: in 30 Of 34 patients with complicated urinary tract infection, clinical efficacy was evaluated by the criteria proposed by the Japanese UTI Committee. Excellent and moderate responses were obtained in 66.7% of 30 patients.<BR>2) Bacteriological effect: 51 strains were isolated before SBT·ABPC treatment, and 33 of these were eradicated after treatment. Seven new strains appeared after treatment.<BR>3) Adverse effects: flushing, pyrexia and itching were observed in 1 case. Noted as clinical laboratory test abnormalities were increase of GOT, GPT and Al-P in 1 case.<BR>From the results obtained in this study, we consider SBT.ABPC to be effective in the treatment of urinary tract infections, especially those due to β-lactamase-producing organisms.

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