CEFOTIAM HEXETIL IN THE SURGICAL FIELD
-
- YURA JIRO
- First Department of Surgery, School of Medicine, Nagoya City University
-
- SHINAGAWA NAGAO
- First Department of Surgery, School of Medicine, Nagoya City University
-
- MIZUNO AKIRA
- First Department of Surgery, School of Medicine, Nagoya City University
-
- MASHITA KEIJI
- First Department of Surgery, School of Medicine, Nagoya City University
-
- HORI KEIICHI
- First Department of Surgery, School of Medicine, Nagoya City University
-
- YOSHIMI OSAMU
- Department of Surgery, Tokai Teishin Hospital
-
- ISHIKAWA SHU
- Department of Surgery, Tokai Teishin Hospital
-
- IWAI AKIHIKO
- Department of Surgery, Chita Kohsei Hospital
-
- MIZUNO HIROSHI
- Department of Surgery, Chita Kohsei Hospital
-
- HAYAKAWA TETSUSHI
- Department of Surgery, Chita Kohsei Hospital
-
- HASHIMOTO TAKASHI
- Department of Surgery, Takahama City Hospital
Bibliographic Information
- Other Title
-
- 外科領域におけるCefotiam hexetilの臨床的検討
Abstract
We performed basic and clinical studies on cefotiam hexetil (CTM-HE), a new oral cephalosporin pro-drug of cefotiam (CTM) in the surgical field.<BR>The results are as follows:<BR>1) Antibacterial activity: MICS of CTM were determined for three clinical isolates: Staphylococcus aureus, Escherichia coli and Klebsiella pneumoniae. Peak values were 1.6μg/ml, 0.2μg/ml and 0.2μg/ml, respectively. These values surpassed those of cefaclor (CCL) and amoxicillin (AMPC) against the same organisms. However, cefotiam hexetil was not shown to be better than cefixime (CFIX) against K. pneumoniae.<BR>2) Clinical results: cefotiam hexetil was used in treating 15 patients with soft tissue infections. Results were excellent in 5 cases, good in 8 and fair in 2. The efficacy rate was 86.7%. Adverse reactions were observed in only 1 case, and clinical laboratory tests revealed no abnormalities.
Journal
-
- CHEMOTHERAPY
-
CHEMOTHERAPY 36 (Supplement6), 694-702, 1988
Japanese Society of Chemotherapy
- Tweet
Keywords
Details 詳細情報について
-
- CRID
- 1390001206284297472
-
- NII Article ID
- 130004196443
-
- ISSN
- 18845894
- 00093165
-
- Data Source
-
- JaLC
- CiNii Articles
-
- Abstract License Flag
- Disallowed