METABOLIC STUDIES ON PANIPENEM/BETAMIPRON DISTRIBUTION, METABOLISM AND EXCRETION OF PANIPENEM/BETAMIPRON IN RATS AND DOGS

DOI

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Other Title
  • Panipenem/betamipronの実験動物における体内動態ラットおよびイヌにおけるpanipenem/betamipronの分布, 代謝および排泄

Abstract

Drug metabolism and disposition studies on panipenem/betamipron (PAPM/BP) were performed by using 14C-labeled panipenem ([14C] PAPM) and betamipron ([14C]BP).<BR>Drugs were administered intravenously as [14C] PAPM/BP, PAPM/[14C] BP, [14C] PAPM or [14C] BP in rats and dogs.[14C] PAPM and [14C] BP were mainly excreted to the urine after being distributed to the kidney, liver, lung or blood. Plasma concentration, excretion rate or tissue distribution of radioactivity in rats between [14C] PAPM/BP and [14C] PAPM alone and between PAPM/[14C] BP and [14C] BP alone gave almost no differences except in the kidney distribution.<BR>In the kidney, the maximum distribution time of [14C] PAPM was delayed by combination dose with BP.

Journal

  • CHEMOTHERAPY

    CHEMOTHERAPY 39 (Supplement3), 206-226, 1991

    Japanese Society of Chemotherapy

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