NY-198の体内動態II

DOI

書誌事項

タイトル別名
  • DISPOSITION AND METABOLISM OF NY-198 II
  • HPLC AND BIOASSAY STUDIES OF ABSORPTION AND EXCRETION IN THE DOG
  • HPLC法とBioassay法によるイヌにおける吸収, 排泄

抄録

We investigated serum levels and urinary excretion of NY-198 using HPLC and bioassay methods after oral administration to dogs at a dose of 20mg/kg.<BR>Average serum levels of NY-198 reached a peak concentration of 8.95μg/ml at 1 h after oral dosing, and then declined with a half-life of 7.1h.<BR>NY-198 was excreted rapidly in urine after oral dosing, and the peak concentration was obtained in 6-12hurine. A high urinary concentration of more than 50μg/ml was maintained up to 48h. Urinary excretion was 40.3% at 24 h and 51.8% at 72h.<BR>Concentrations of NY-198 in serum and urine were measured by both HPLC and bioassay, and good correlation between the two assays was obtained. These results suggest that active metabolites possesing antimicrobial activity are not present in serum or urine after oral administration of NY-198.

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