わが国の健常人における植物スタノールエステル含有スプレッドの血清脂質，アポリポタンパクに対する影響　　無作為割付による３群比較試験

DOI Web Site 被引用文献3件 参考文献17件

書誌事項

タイトル別名
  • Cholesterol- and Apolipoptotein-lowering Effect of Plant Stanol Ester in Healthy Japanese Men and Women. A Randomized, Placebo-controlled Study.
  • ワガクニ ノ ケンジョウジン ニ オケル ショクブツ スタノールエステル ガンユウ スプレッド ノ ケッセイ シシツ アポリポタンパク ニ タイスル エイキョウ ムサクイ ワリツケ ニ ヨル 3グン ヒカク シケン
  • A Randomized, Placebo-controlled Study
  • 無作為割付による3群比較試験

この論文をさがす

抄録

We evaluated the effectiveness of consuming a spread containing plant stanol esters for reducing total cholesterol, low-density lipoprotein (LDL)-cholesterol and apolipoprotein B in Japanese adults with mildly elevated serum cholesterol levels. One hundred and five subjects were randomized to receive one of the following spreads containing plant stanol ester or placebo for 4 weeks: placebo spread; 1g plant stanol as stanol esters twice a day (3.4g plant stanol esters); or 1g plant stanol 3 times a day (5.1g plant stanol esters). The 4-week treatment period was followed by a 4-week follow-up period without treatment. Lipid levels were estimated at the baseline and at weeks 2, 4 and 8. Apoproteins were estimated at the baseline and at week 4. Levels of total cholesterol, LDL-cholesterol and apoprotein B were significantly reduced by 6.3%, 9.5% and 7.1%, respectively, after 4 weeks of daily treatment with 2g plant stanol as stanol esters. Levels of total cholesterol and LDL-cholesterol returned to the baseline after the 4-week follow-up period without treatment. No further reductions were observed in the group consuming 3g plant stanol as stanol esters per day. Levels of triglyceride (TG), high-density lipoprotein (HDL)-cholesterol and apoprotein Al were not changed by consumption of plant stanol esters. No clinically significant side effects were observed. Thus, plant stanol esters significantly reduced the levels of total cholesterol, LDL cholesterol and apoprotein B without any significant side effects in a mildly hypercholesterolemic Japanese population. These findings demonstrate that plant stanol esters are an effective dietary adjunct for reducing cholesterol levels.

収録刊行物

被引用文献 (3)*注記

もっと見る

参考文献 (17)*注記

もっと見る

キーワード

詳細情報 詳細情報について

問題の指摘

ページトップへ