The Water Retention Effects and Action for Atopic Dermatitis-like Symptoms of Ethyl Alcohol Extract (from Tamogi-take Mushroom) on Animal Model of Atopic Dermatitis

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  • Tomiyama Takahiro
    Three-B Co. Ltd.
  • Kaihou Shinobu
    Three-B Co. Ltd.
  • Ishida Masami
    Three-B Co. Ltd.
  • Nishikawa Hidetoshi
    New Drug Development Research Center, Inc.
  • Yamazaki Noriyuki
    New Drug Development Research Center, Inc.
  • Tsuji Kiyomi
    Laboratory of Biomembrane and Biofunctional Chemistry, Faculty of Pharmaceutical Sciences and Faculty of Advanced Life Sciences, Hokkaido University
  • Mitsutake Susumu
    Laboratory of Biomembrane and Biofunctional Chemistry, Faculty of Pharmaceutical Sciences and Faculty of Advanced Life Sciences, Hokkaido University
  • Igarashi Yasuyuki
    Laboratory of Biomembrane and Biofunctional Chemistry, Faculty of Pharmaceutical Sciences and Faculty of Advanced Life Sciences, Hokkaido University

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Other Title
  • タモギタケエタノール抽出物のアトピー性皮膚炎モデルマウスを用いた保湿作用およびアトピー様症状に対する作用
  • タモギタケ エタノール チュウシュツブツ ノ アトピーセイ ヒフエン モデル マウス オ モチイタ ホシツ サヨウ オヨビ アトピーヨウ ショウジョウ ニ タイスル サヨウ

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Abstract

Most patients with atopic dermatitis suffer from dry skin, deterioration of epidermal barrier function, and dermatitis. Hairless mice (HR-1) are a well known animal model for studies of skin abnormalities such as atopic dermatitis. Atopic dermatitis-like symptoms can be induced in these animals by feeding them a specific diet, known as the HR-AD. Using this animal model, we examined the effects of oral administration of an ethyl alcohol extract of tamogi-take, an edible mushroom that contains a high concentration of glucosyl ceramide (hereafter referred to as tamogi-take extract), on atopic dermatitis. The control group (HR-AD-fed mice) showed typical atopic dermatitis, with gradual transepidermal water loss (TEWL), keratinization and cellular infiltration into dermis. However, these conditions were ameliorated in the mice fed the tamogi-take extract (oral administration weight % of tamogi-take extract: 0.1% and 0.01% as glucosyl ceramide). Thus, in this study using hairless mice, epidermal barrier dysfunction induced by HR-AD was shown to be ameliorated by oral administration of tamogi-take extract.

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