Effects of Phosphoryl Oligosaccharides of Calcium (POs-Ca) on Epidermal Cells and Human Skin
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- Sambe Haruyo
- Institute of Health Sciences, Ezaki Glico Co., Ltd.
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- Sugimoto Kazuhisa
- Institute of Health Sciences, Ezaki Glico Co., Ltd.
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- Nomura Koji
- Institute of Health Sciences, Ezaki Glico Co., Ltd.
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- Kuriki Takashi
- Institute of Health Sciences, Ezaki Glico Co., Ltd.
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Abstract
Phosphoryl oligosaccharides of calcium (POs-Ca) is a calcium salt of phosphoryl maltooligosaccharides made from potato starch. POs-Ca has high solubility in water and it can supply both calcium ion and acidic oligosaccharides in an aqueous medium. In this study, we evaluated effects of POs-Ca on cultured normal human epidermal keratinocytes (NHEK) and human skin. Several in vitro studies using cultured NHEK demonstrated that POs-Ca promoted NHEK differentiation, tight junction formation, intercellular lipid production, and gene expression involved in stratum corneum condition, skin barrier function and hydration. Skin penetration study using a three-dimensional epidermal model demonstrated that POs-Ca was able to provide both calcium ion and phosphoryl oligosaccharides to the epidermis. Furthermore, an in vivo study demonstrated that POs-Ca improved human skin conditions including hydration, barrier function, stratum corneum condition, and skin texture. These results suggest that POs-Ca can be a superior active agent for healthy epidermis.
Journal
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- Journal of Applied Glycoscience
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Journal of Applied Glycoscience 62 (3), 107-113, 2015
The Japanese Society of Applied Glycoscience
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Keywords
Details 詳細情報について
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- CRID
- 1390001206291696640
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- NII Article ID
- 130005094610
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- NII Book ID
- AA11809133
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- ISSN
- 18807291
- 13447882
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- NDL BIB ID
- 026695808
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- Text Lang
- en
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- Data Source
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- JaLC
- NDL
- Crossref
- CiNii Articles
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- Abstract License Flag
- Disallowed