Plasma Magnesium and Calcium Response to Oral-administration of Magnesium in Rats Fed Normal, Magnesium-free, and Mineral-free Diets.

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  • PENG Yu
    The United Graduate School of Agricultural Science, Gifu University
  • TAKEUCHI Hisanao
    Department of Applied Biological Chemistry, Faculty of Agriculture, Shizuoka University

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  • 正常食，マグネシウム欠食およびミネラル欠食投与ラットにおけるマグネシウム経口投与による血しょうのマグネシウムおよびカルシウムの応答
  • セイジョウショク,マグネシウム ケッショク オヨビ ミネラル ケッショク トウヨ ラット ニ オケル マグネシウム ケイコウ トウヨ ニ ヨル ケッショウ ノ マグネシウム オヨビ カルシウム ノ オウトウ

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Male Wistar rats weighing about 130g were fed normal, magnesium-deficient, and mineral-deficient diets for seven days. At 0, 0.25, 0.5, 1, 2, 4, 6, and 8h after orally administering 10, 20, and 40mg Mg/rat via a stomach tube to animals deprived of food for 16h immediately before the end of feeding, blood was obtained from a tail vein, and then the intestines were removed immediately after decapitation 8h later. The magnesium levels in plasma and the intestines were the determined. With the administration of 10mg Mg, the plasma magnesium concentration increased with time, reached a maximum level about 2h after administration, and then reduced slowly in all dietary groups. At about 0.5h after administering 20mg Mg, the maximum level of plasma magnesium increased and the level was maintained nearly constant for more than 8h in all groups. The amounts of magnesium administered tended to be correlated with the time taken to attain the maximum level of plasma magnesium. With 40mg Mg, the most of rats died with in 2h after administration. The enhancement of the plasma magnesium concentration in the mineral-deficient group was the greatest among the three groups. Kinetic analyses of the results suggested that the absorption of magnesium was a first-order process, the absorption rate of magnesium was much greater than its distribution (disappearance) rate, and the apparent volume of distribution in the normal group was much higher than those in the magnesium-deficient and mineral-deficient groups. Especially, it was suggested that in rats fed the mineral-deficient diets, the distribution volume of magnesium was reduced by the supply of a great deal of magnesium, which caused the rats to die.

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