スナネズミ（Ｍｅｒｉｏｎｅｓ　ｕｎｇｕｉｃｕｌａｔｕｓ）の肝および胃におけるアルコール脱水素酵素アイソザイムに関する研究　ラット・マウスおよびモルモットとの比較

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  • Comparative Studies on Alcohol Dehydrogenase Isozymes in the Liver and Stomach of Meriones unguiculatus, Rat, Mouse and Guinea Pig.
  • スナネズミ Meriones unguiculatus ノ カン オヨビ イ

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The multiplicity of alcohol dehydrogenase (ADH) isozymes was examined in the liver and stomach of Mongolian gerbils. Four ADH isozymes were resolved and distinguished on the basis of their electrophoretic mobilities, tissue distributinns, and substrate and inhibitor specificities. Compared with the ADH isozyme systems reported previously in the mouse, rat and guinea pig, class I and II ADHs were identified in the liver and class IV ADH in the stomach of the Mongolian gerbil. Class III ADH was detected in both organs. Thus, the ADH systems of the Mongolian gerbil seem to be identical to thase of other rodents. Liver ADH of the Mongolian gerbil showed similar activity to those of the mouse and rat, and was significantly higher than that of the guinea pig, towards either 15mM ethanol or 5mM hexenol. However, stomach ADH activity in the Mongolian gerbil, as well as that of the guinea pig, was much lower than those of the mouse and rat for both substrates. The activity in both species was also much lower than the liver ADH activities even at higher concentrations of ethanol, although ADH activities in the mouse and rat for 500mM ethanol were abvut twice as high in the stomach as in the liver. Accardingly, the first-pass metabalism of alcohol in the stomach would appear to proceed to a lesser extent in the Mongolian gerbil and guinea pig. Furthermore, the lower activity of stomach ADH for hexenol found in the Mongolian gerbil and guinea pig seems to reflect the feeding habits of these animals.

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