ブラックマッペのアンジオテンシンＩ変換酵素阻害因子の検索

DOI Web Site 被引用文献1件 参考文献21件

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タイトル別名
  • Angiotensin I-Converting Enzyme Inhibitory Substances in Black Matpe.
  • ブラック マッペ ノ アンジオテンシン 1 ヘンカン コウソ ソガイ インシ

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Crude extracts of black matpe showed ACE inhibitory activity. The Sephadex G-100 gel filtration patterns of these extracts indicated that the ACE inhibitory activity was present in the low-molecular-weight fraction. The Sephadex G-15 gel filtration patterns of the active fraction obtained from the Sephadex G-100 column indicated that the molecular weight of the inhibitors was about 400-800. The active fractions obtained from the Sephadex G-15 column were purified by HPLC using an ODS column. The active fractions were not absorbed, and were eluted with 0.05% trifluoroacetic acid. The ACE inhibitory activity of seeds germinated for 6 days was 40% of that of the black matpe extracts. Oral and intraperitoneal administration of a pepsin hydrolysate of the black matpe extract decreased the blood pressure of SHR rats significantly.

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